He made the remarks in his Vesak Day statement, Xinhua news agency reported on Thursday.
Wickremesinghe said that Sri Lanka as a nation should cultivate the same great zeal for enlightenment that Buddha exemplified, to sacrifice today for a better tomorrow.
Wickremesinghe joined the Vesak festival on Thursday virtually and extended his wishes to all Buddhists for a meaningful Vesak celebration.
On Thursday, he also granted the presidential pardon to 278 prisoners to mark Vesak Day, the most important religious event for Buddhists, the prison's department said in a statement.
Sri Lanka usually pardons prisoners on Independence Day and during major religious events.
These amnesties do not apply to those convicted of murder, serious drug offences, rape, and armed robbery.